These abnormalities account for many prenatal birth defects and can contribute to the origins of cancer.īetter understanding cellular mitosis increases our chances of diagnosing, treating, and preventing those mitotic defects. When those misfires occur, the resulting cell will continue to duplicate copies of its faulty self, creating genetic defects that could cause widespread problems in a living body. Sometimes, cells divide unevenly, or chromosomes can become unevenly split. As new cells perform the same function over and over, they form organs, heal wounds, and replace dead cells, sustaining the cycle of healthy tissues and organs.īut cell division doesn't always happen this smoothly. A cell, at its most fundamental level, duplicates its chromosomes, which are then separated and distributed equally between two daughter cells, each with its own complete set of genetic information. The work received funding from the National Science Foundation and support from both the Virginia Tech Institute for Critical Technology and Applied Science and the Virginia Tech Macromolecules Innovation Institute.Ĭell division, called mitosis, is essential for developmental, repair, and disease biology. The findings were published in the Proceedings of the National Academy of Sciences on Feb.
#Spindle biology windows
Cells are typically studied in a flat environment, and the difference between flat and fibrous landscapes opens new windows into the behavior of cells and the diseases that impact them. His latest collaboration investigates how cells divide, particularly in the fibrous environment of living tissue. His past work has analyzed how cells move and even included projects with colleagues to measure cell forces and nucleus shapes and to electrify cells and observe how they heal. Over the past several years, Nain has taken many journeys down the microscopic roads where cells live. The mechanics he champions are the tiny building blocks of life and how they behave and move.Ĭellular dynamics research studies living cells and their life, death, division, and multiplication. Amrinder Nain is an associate professor in the Department of Mechanical Engineering, but he doesn't build cars or robots.
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